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Differential RNASeq of human bronchial and nasal epithelial cells stimulated with RIG-I ligand SLR14

ABSTRACT: Differential RNASeq of human bronchial and nasal epithelial cells stimulated with RIG-I ligand SLR14

PROVIDER: PRJNA483482 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6365590_1.fastq.gz	Fastqsanger.gz
	SRR6365590_2.fastq.gz	Fastqsanger.gz
	SRR6365591_1.fastq.gz	Fastqsanger.gz
	SRR6365591_2.fastq.gz	Fastqsanger.gz
	SRR6365603_1.fastq.gz	Fastqsanger.gz

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Differential RNASeq of human bronchial epithelial cells stimulated with RIG-I ligand SLR14

Project description:Differential RNASeq of human bronchial epithelial cells stimulated with RIG-I ligand SLR14

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Differential RNASeq of human nasal epithelial cells stimulated with RIG-I ligand SLR14

Project description:Differential RNASeq of human nasal epithelial cells stimulated with RIG-I ligand SLR14

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Differential RNASeq of human nasal epithelial cells stimulated with RIG-I ligand SLR14

Project description:The purpose of this study was to assess transcriptome changes in primary human airway epithelial cells following stimulation with RIG-I ligand.

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Differential RNASeq of human bronchial epithelial cells stimulated with RIG-I ligand SLR14

Project description:The purpose of this study was to assess transcriptome changes in primary human airway epithelial cells following stimulation with RIG-I ligand.

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Exploring intrinsic variability between cultured nasal and bronchial epithelia in cystic fibrosis

Project description:The nasal and bronchial epithelium are unified parts of the respiratory tract that are affected in the monogenic disorder cystic fibrosis (CF). Recent studies have uncovered that nasal and bronchial tissues exhibit intrinsic variability, including differences in mucociliary cell composition and expression of unique transcriptional regulatory proteins which relate to germ layer origin. In the present study, we explored transcriptomic differences between cultured nasal and bronchial epithelial cells from people with CF. Comparison of air-liquid interface-differentiated epithelial cells from subjects with CF revealed distinct mucociliary differentiation states of nasal and bronchial cultures. Moreover, using RNA sequencing we identified cell type-specific signature transcription factors in differentiated nasal and bronchial epithelial cells.

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Gene expression from bronchial and nasal epithelial cell samples of healthy current and never smokers.

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Gene expression from bronchial and nasal epithelial cell samples of healthy current and never smokers.

Project description:mRNA expression was assayed from bronchial epithelial cells collected via bronchoscopy and nasal epithelial cells collected by brushing the inferior turbinate from healthy current and never smoker volunteers in order to determine the relationship between smoking-related gene expression changes in bronchial and nasal epithelium within the same individual. Bronchial epithelial cells were collected from current and never smokers via bronchoscopy, and nasal epithelial cells were collected by brushing the inferior turbinate during the same clinic visit. 1ug of RNA was isolated and hybridized to Affymetrix Human Exon 1.0 ST microarrays to obtain mRNA expression. The genome build upon which transcript assignments are based is hg18 (HuEx-1_0-st-v2.na27.hg18.transcript.csv).

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NextGeneration Sequencing of Pediatric ARDS Nasal and Bronchial Brushings

Project description:The objective of this study was to determine if nasal transcriptomics could be used to characterize the underlying pathobiology and predict clinical course of patients with pediatric ARDS (PARDS). Subjects meeting consensus PARDS criteria or controls admitted to the Pediatric ICU without lung disease had nasal cytology brushings on days 1, 3, 7 and 14. The gene expression of these brushings was compared to identify subtypes and describe clinical course. Concurrent nasal and bronchial brushings were collected if bronchoscopy was performed. We identified four PARDS subgroups, termed A, B, C, and D. Subgroup B was marked by inflammation and ciliary cell dysfunction. Subgroup D was marked by reduced epithelial stem cell mRNAs without inflammation. Subgroup A had hypo-inflammation and upregulation of pathways important in epithelial cell repair. Subgroup C had increased ciliary cell genes. Control specimens almost entirely clustered with Subgroup C, but one that developed PARDS clustered with Subgroup B and several that developed lung injury clustereced with Subgroups B and A. Over time, Subgroups D and B transitioned to A which transitioned to C. Bronchial and nasal gene expresison were similar.

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Differential RNASeq of human bronchial and nasal epithelial cells stimulated with RIG-I ligand SLR14

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-07-30 | GSE117884 | GEO

methyl-Seq of Pediatric ARDS Nasal and Bronchial Brushings

Project description:The objective of this study was to identify differences in the nasal methylome of patients with Pediatric ARDS (PARDS) compared to controls and to observe how this might change over time. We found two different methylomic patterns. Subgroup 1 was comprised of entirely of PARDS subjects, and Subgroup 2 contained both control and PARDS subject. Subgroup 1was characterized by hypomethylation of genes related to cell adhesion and hypermethylation of cell metabolism-related genes. Over time, the methylation pattern of PARDS subjects changed, but the pattern of control subjects was stable. Five concurrent bronchial and nasal specimens were obtained showing very few differences in methylation between these two collection sites.

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