Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Differential RNASeq of human nasal epithelial cells stimulated with RIG-I ligand SLR14

ABSTRACT: Differential RNASeq of human nasal epithelial cells stimulated with RIG-I ligand SLR14

PROVIDER: PRJNA421899 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6365603_1.fastq.gz	Fastqsanger.gz
	SRR6365603_2.fastq.gz	Fastqsanger.gz
	SRR6365604_1.fastq.gz	Fastqsanger.gz
	SRR6365604_2.fastq.gz	Fastqsanger.gz
	SRR6365605_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Differential RNASeq of human nasal epithelial cells stimulated with RIG-I ligand SLR14

Project description:The purpose of this study was to assess transcriptome changes in primary human airway epithelial cells following stimulation with RIG-I ligand.

2018-01-02 | GSE107898 | GEO

Differential RNASeq of human bronchial and nasal epithelial cells stimulated with RIG-I ligand SLR14

Project description:Differential RNASeq of human bronchial and nasal epithelial cells stimulated with RIG-I ligand SLR14

| PRJNA483482 | ENA

Differential RNASeq of human bronchial epithelial cells stimulated with RIG-I ligand SLR14

Project description:The purpose of this study was to assess transcriptome changes in primary human airway epithelial cells following stimulation with RIG-I ligand.

2018-08-17 | GSE107897 | GEO

Differential RNASeq of human bronchial epithelial cells stimulated with RIG-I ligand SLR14

Project description:Differential RNASeq of human bronchial epithelial cells stimulated with RIG-I ligand SLR14

| PRJNA421897 | ENA

Differential RNASeq of human bronchial and nasal epithelial cells stimulated with RIG-I ligand SLR14

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-07-30 | GSE117884 | GEO

Gene expression changes upon activation of RIG-I by a minimal potent RIG-I ligand

Project description:Gene expression changes upon activation of RIG-I by a minimal potent RIG-I ligand

| PRJNA418284 | ENA

Gene expression changes upon activation of RIG-I by a minimal potent RIG-I ligand

Project description:We have developed highly potent synthetic activators of the vertebrate immune system that specifically target the RIG-I receptor. When introduced into mice, a family of short, triphosphorylated Stem Loop RNAs (SLRs) induces a potent interferon response and the activation of specific genes essential for antiviral defense. Using RNAseq, we provide the first in-vivo genome-wide view of the expression networks that are initiated upon RIG-I activation. We observe that SLRs specifically induce type I interferons, subsets of interferon-stimulated genes (ISGs), and cellular remodeling factors. By contrast, poly(I:C), which binds and activates multiple RNA sensors, induces type III interferons and several unique ISGs. The short length (10-14 base pairs) and robust function of SLRs in mice demonstrate that RIG-I forms active signaling complexes without oligomerizing on RNA. These findings demonstrate that SLRs are potent therapeutic and investigative tools for targeted modulation of the innate immune system.

2018-02-03 | GSE106229 | GEO

RNA-seq comparison of gene induction in RIG-I stimulated old and young human monocytes

Project description:Goal: The goal of this study was to compare gene induction in old and young human monocytes upon stimulation of these cells with a RIG-I specific ligand, based on previously published results which indicated impaired interferon responses in monocytes from older individuals upon influenza virus infeciton.

2017-12-31 | GSE100709 | GEO

Transcriptomic analysis of Clec12A-deficient BMDCs stimulated with RIG-I agonist

Project description:Transcriptomic analysis of Clec12A-deficient BMDCs stimulated with RIG-I agonist

| PRJNA553706 | ENA

Effect of DNA damage on ligand stimulated EGFR signaling pathways

Project description:Effect of DNA damage on ligand stimulated EGFR signaling pathways

| PRJNA759859 | ENA