Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single cell RNA-seq of long-term hematopoietic stem cells (LT-HSCs) and common myeloid progenitors (CMPs)

ABSTRACT: We aimed to reseach the differences between IL4Rα high and low expression LT-HSC/CMP,our data revealed distinct sensitivities of HSCs and common myeloid progenitors (CMPs) to IL4-induced apoptosis, and IL4Rahigh HSCs were more susceptible to unfolded protein response (UPR) and irradiation-induced apoptosis.

ORGANISM(S): Mus musculus

PROVIDER: GSE109324 | GEO | 2020/06/25

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene expression profiling of LT-HSCs and ST-HSCs conditionally expressing MLL-ENL

Project description:We have developed a new conditional transgenic mouse showing that MLL-ENL, at an endogenous-like expression level, induces leukemic transformation selectively in LT-HSCs. To investigate the molecular mechanism of leukemic transformation in LT-HSCs conditionally expressing MLL-ENL, we preliminarily performed comprehensive gene expression profiling of CreER-transduced LT-HSCs and ST-HSCs using cDNA microarray analysis. For initial screening of candidate genes invloved in the leukemic transformation, total RNA was extracted from colony-forming cells derived from LT-HSCs and ST-HSCs transduced with CreER or mock. Four samples were analyzed, and CreER-transduced LT/ST-HSC-derived cells were compared with mock-transduced LT/ST-HSC-derived cells, while CreER/mock-transduced LT-HSC-derived cells were compared with CreER/mock-transduced ST-HSC-derived cells.

2013-07-17 | E-GEOD-48539 | biostudies-arrayexpress

Gene expression profiling of LT-HSCs and ST-HSCs conditionally expressing MLL-ENL

2013-07-17 | GSE48539 | GEO

Single cell RNA-seq of long-term hematopoietic stem cells (LT-HSCs) and common myeloid progenitors (CMPs)

Project description:Single cell RNA-seq of long-term hematopoietic stem cells (LT-HSCs) and common myeloid progenitors (CMPs)

| PRJNA430432 | ENA

Methylomes of young and aged LT-HSCs

Project description:We performed tagmentation-based whole-genome bisulfite sequencing on young and aged LT-HSCs.

2021-03-01 | GSE167891 | GEO

Ex vivo cultured mouse LT-HSCs RNA-seq

Project description:Mouse LT-HSCs were co-cultured with polymer nanospheres for ex vivo expansion

2024-03-10 | GSE198442 | GEO

Identification of Fam122a regulated genes in LT-HSCs.

Project description:We report differences in gene expression between WT and Fam122a KO LT-HSCs.

2020-05-28 | GSE151261 | GEO

circular RNA profiling of LT-HSCs and MPPs

Project description:Investigation of circular RNAs that have a higher expression level in LT-HSCs

2016-05-01 | GSE79126 | GEO

Loss of Phf6 prevents aging associated transcriptomic profile changes in LT-HSCs

Project description:Loss of Phf6 prevents the functional decline and immunophenotypic changes associated with age-related, long-term repopulating hematopoietic stem cell (LT-HSC) exhaustion. To identify the underlying molecular mechanisms that account for these differences, we performed RNA-seq profiling of LT-HSCs isolated from the bone marrow of Phf6 wild-type and knock-out, young (16-week-old) and aged (24-month-old) C57BL/6 mice. Our analysis revealed that LT-HSCs isolated from 24-month-old, Phf6 knockout mice retained the molecular signatures associated with young LT-HSCs whereas LT-HSCs isolated from aged, Phf6 wild-type mice acquired signatures consistent with HSC exhaustion. Mechanistically, these data revealed important roles for key metabolic pathways including glutathione metabolism and sterol biosynthesis, as well as cell-cell interaction and signaling pathways such as the interferon and TGF-beta responses.

2022-11-01 | GSE165695 | GEO

Methylomes of young and aged LT-HSCs

Project description:Methylomes of young and aged LT-HSCs

| PRJNA705470 | ENA

ATAC-seq of LT-HSCs and MPPs

Project description:ATAC-seq of LT-HSCs and MPPs

| PRJEB41482 | ENA