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Near-term fetal sheep pulmonary artery endothelial cells in a model of intrauterine growth restriction (IUGR)

ABSTRACT: Isolated PAECs gene expression was tested in cultured cells from control or hyperthermia-treated pregnant sheep (IUGR model) to measure gene expression changes.

ORGANISM(S): Ovis aries

PROVIDER: GSE109939 | GEO | 2018/05/22

REPOSITORIES: GEO

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Near-term fetal sheep pulmonary artery endothelial cells in a model of intrauterine growth restriction (IUGR)

Project description:Near-term fetal sheep pulmonary artery endothelial cells in a model of intrauterine growth restriction (IUGR)

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Placental microRNA expression in pregnancies complicated by Intrauterine growth restriction (IUGR) and preeclampsia (PE)

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Comparative analysis of ovine fetal skeletal muscle gene expression: control and intrauterine growth restriction (IUGR)

Project description:Impaired muscle growth as a result of IUGR is a major contributor to lifelong reductions in muscle mass (sarcopenia) and metabolic disease risk. We use an ovine model of chronic placental insufficiency which restricts nutrient supply from mother to fetus and results in intrauterine growth restriction. In our model of placental insufficiency and IUGR, fetal hindlimb muscles weigh less than normally-grown control fetuses and have smaller myofiber diameters. Given the frequent correlation between functional changes and transcriptional changes, we investigated the effect of chronic placental insufficiency and IUGR on fetal skeletal muscle gene expression. We found that gene expression in the skeletal muscle is significantly altered by chronic placental insufficiency. In gene ontology analysis, we found that genes involved in cell cycle regulation were most significantly affected, with downregulation of several cyclins. These observations may in part account for decreased muscle weight relative to brain weight observed in the late gestation IUGR fetus.

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Placenta Transcriptome Profiling in Intrauterine Growth Restriction (IUGR).

Project description:Intrauterine growth restriction (IUGR) is a serious pathological complication associated with compromised fetal development during pregnancy. The aim of the study was to broaden knowledge about the transcriptomic complexity of the human placenta by identifying genes potentially involved in IUGR pathophysiology. RNA-Seq data were used to profile protein-coding genes, detect alternative splicing events (AS), single nucleotide variant (SNV) calling, and RNA editing sites prediction in IUGR-affected placental transcriptome. The applied methodology enabled detection of 37,501 transcriptionally active regions and the selection of 28 differentially-expressed genes (DEGs), among them 10 were upregulated and 18 downregulated in IUGR-affected placentas. Functional enrichment annotation indicated that most of the DEGs were implicated in the processes of inflammation and immune disorders related to IUGR and preeclampsia. Additionally, we revealed that some genes (S100A13, GPR126, CTRP1, and TFPI) involved in the alternation of splicing events were mainly implicated in angiogenic-related processes. Significant SNVs were overlapped with 6533 transcripts and assigned to 2386 coding sequence (CDS), 1528 introns, 345 5' untranslated region (UTR), 1260 3'UTR, 918 non-coding RNA (ncRNA), and 10 intergenic regions. Within CDS regions, 543 missense substitutions with functional effects were recognized. Two known mutations (rs4575, synonymous; rs3817, on the downstream region) were detected within the range of AS and DEG candidates: PA28β and PINLYP, respectively. Novel genes that are dysregulated in IUGR were detected in the current research. Investigating genes underlying the IUGR is crucial for identification of mechanisms regulating placental development during a complicated pregnancy.

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RNA Sequencing of Pancreatic Islets from Intrauterine Growth Restricted and Normally-Grown Near Term Sheep Fetuses

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History of periodontal treatment and risk for intrauterine growth restriction (IUGR).

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Transcriptome analyses reveal metabolic syndrome of adulthood with intrauterine growth restriction in a pig model

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