Proteomics

Dataset Information

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Proteomic analysis of liver proteome affected by intrauterine growth restriction in newborn piglets.


ABSTRACT: Intrauterine growth restriction (IUGR) impairs fetal growth and development, perturbs nutrient metabolism, and increases the risk of developing diseases in the postnatal life. However, the underlying mechanisms by which IUGR affects fetuses remain incompletely understood. Here, we applied high-throughput proteomics approach and biochemical analysis to investigate the impact of IUGR on fetal liver.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Hepatocyte, Liver

SUBMITTER: Baisheng Long  

LAB HEAD: Xianghua Yan

PROVIDER: PXD003524 | Pride | 2016-03-15

REPOSITORIES: Pride

Dataset's files

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Publications

Global Liver Proteome Analysis Using iTRAQ Reveals AMPK-mTOR-Autophagy Signaling Is Altered by Intrauterine Growth Restriction in Newborn Piglets.

Long Baisheng B   Yin Cong C   Fan Qiwen Q   Yan Guokai G   Wang Zhichang Z   Li Xiuzhi X   Chen Changqing C   Yang Xingya X   Liu Lu L   Zheng Zilong Z   Shi Min M   Yan Xianghua X  

Journal of proteome research 20160311 4


Intrauterine growth restriction (IUGR) impairs fetal growth and development, perturbs nutrient metabolism, and increases the risk of developing diseases in postnatal life. However, the underlying mechanisms by which IUGR affects fetal liver development and metabolism remain incompletely understood. Here, we applied a high-throughput proteomics approach and biochemical analysis to investigate the impact of IUGR on the liver of newborn piglets. As a result, we identified 78 differentially expresse  ...[more]

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