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Effect of EcR RNAi on wandering third instar larval fat body gene expression in Drosophila melanogaster

ABSTRACT: We compared ecdysone receptor (EcR)-dependent gene expression in the Drosophila fat body on 0.15 M sucrose and 0.5 M sucrose high-sugar diets in order to gain insight into the role of this gene during caloric overload. Phenotypic analyses showed an increased severity of EcR RNAi phenotypes with increasing dietary sugar concentration. Because EcR is a transcription factor, we performed RNA-seq studies to identify transcriptional targets that might underlie insulin resistance downstream of EcR RNAi.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE110432 | GEO | 2018/02/10

REPOSITORIES: GEO

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