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Effect of Seven-up RNAi on wandering third instar larval fat body gene expression in Drosophila melanogaster

ABSTRACT: We compared Seven-up-dependent gene expression in the Drosophila fat body on control and high-sugar diets in order to gain insight into the role of this gene during caloric overload. Phenotypic analyses showed an increased severity of Seven-up RNAi phenotypes with increasing dietary sugar concentration. Because Seven-up is a transcription factor, we performed RNA-seq studies to identify transcriptional targets that might underlie insulin resistance downstream of Seven-up RNAi. Our data support a model where Seven-up promotes insulin signaling by inhibiting ecdysone receptor target gene expression.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE95800 | GEO | 2018/04/01

REPOSITORIES: GEO

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