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Secondary structure based on icSHAPE of pre-let-7 and hDicer-TRBP bound pre-let-7

ABSTRACT: we resolved precusor let7 (pre-let-7) and human Dicer-TRBP complex bound precusor let7 (hDicer-TRBP-pre-let-7) secondary structure based on in vivo click selective 2'-hydroxyl acylation and profiling experiment (icSHAPE). We found the free pre-let-7 RNA is more flexible comparing with hDicer-TRBP-pre-7 in the double strand region [10-20nt and 50- 60 nt].

ORGANISM(S): Homo sapiens

PROVIDER: GSE110516 | GEO | 2018/02/14

REPOSITORIES: GEO

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