Transcriptomics

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Preclinical model of obesity and ER-positive breast cancer


ABSTRACT: Here, we developed a mouse model of diet induced obesity that is graft competent. In this model, we grew an ER-positive breast cancer patient derived tumor. Following ovariectomy and estrogen deprivation therapy, tumors continued to grow in obese but not lean mice. RNAsequencing analysis was performed on tumors from estrogen-supplemented lean mice, and from lean and obese mice after estrogen deprivation. This analysis identified fibroblast growth factor receptor signaling as a potential driver of tumor progression in the context of obesity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE110644 | GEO | 2019/03/01

REPOSITORIES: GEO

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