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Whole kidneys at embryonic day 16.5: wildtype (WT) vs. conditional Dot1-knockout (KO) from Six2-positive nephron progenitor cells (NPC)

ABSTRACT: Transcriptional profiling of whole kidneys from Six2CreEGFP mice without (WT) or with (KO) homozygously floxed DOT1 alleles at the age of embryonic day 16.5. This experiment aimed to uncover the genome-wide alternation in gene expression resulting from the removal of DOT1 gene in the nephron progenitor population (Six2 positive) and successive changes to the series of events in kidney development.

ORGANISM(S): Mus musculus

PROVIDER: GSE110928 | GEO | 2019/12/31

REPOSITORIES: GEO

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Whole kidneys at embryonic day 16.5: wildtype (WT) vs. conditional Dot1-knockout (KO) from Six2-positive nephron progenitor cells (NPC)

Project description:Whole kidneys at embryonic day 16.5: wildtype (WT) vs. conditional Dot1-knockout (KO) from Six2-positive nephron progenitor cells (NPC)

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Whole kidneys at embryonic day 17.5: wildtype (WT) vs. various combinations of the conditional homozygous Ezh2-knockout (Ezh2-KO) from Six2-positive nephron progenitor cells (NPC) and/or germline Ezh1-knockout (Ezh1-KO)

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Gene expression profiling of Six2-positive nephron progenitors from mouse embryo

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