Transcriptomics

Dataset Information

0

22RV1 prostate cancer cell line transfected with SPINK1 siRNA vs control siRNA


ABSTRACT: ETS gene fusions have been characterized in a majority of prostate cancers, however key molecular alterations in ETS negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier-expression exclusively in a subset of ETS rearrangement negative cancers (~10% of total cases). We validated the mutual exclusivity of SPINK1 expression and ETS fusion status, demonstrated that SPINK1 outlier-expression can be detected non-invasively in urine and observed that SPINK1 outlier-expression is an independent predictor of biochemical recurrence after resection. We identified the aggressive 22RV1 cell line as a SPINK1 outlier-expression model, and demonstrate that SPINK1 knockdown in 22RV1 attenuates invasion, suggesting a functional role in ETS rearrangement negative prostate cancers. Keywords: Genetic Modification

ORGANISM(S): Homo sapiens

PROVIDER: GSE11132 | GEO | 2008/06/10

SECONDARY ACCESSION(S): PRJNA106919

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2008-06-10 | E-GEOD-11132 | biostudies-arrayexpress
2019-12-16 | GSE124345 | GEO
2024-02-26 | PXD043086 | Pride
2018-12-30 | GSE108558 | GEO
| PRJNA511709 | ENA
2015-07-11 | E-GEOD-70761 | biostudies-arrayexpress
2019-11-10 | GSE140179 | GEO
2018-08-30 | GSE108545 | GEO
2014-07-21 | GSE55016 | GEO
2013-07-20 | E-GEOD-40383 | biostudies-arrayexpress