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Transcriptomic analysis of CD44+CD62L- CD8+ T cells purified from tumors and lymph nodes (LN) of whole-body irradiated or unirradiated MC38 tumor-bearing mice, by microarray

ABSTRACT: In the present manuscript we show that T cells within tumors are highly radio-resistant compared to T cells in lymphoid organs. To better understand this different response to ionizing radiation (IR), gene expression is compared for T cells from lymph nodes and those from transplantable MC38 tumors, in mice treated or not with whole body irradiation. We find that T cells from tumors and lymph nodes respond similarly to IR in terms of gene expression, and this response is dominated by p53 signaling. In contrast, gene expression at baseline (i.e. in the absence of radiation) shows profound differences between T cells from tumors and T cells from lymph nodes, and suggests transcriptomic reprogramming of the intratumoral T cells in the tumor microenvironment .

ORGANISM(S): Mus musculus

PROVIDER: GSE111492 | GEO | 2019/07/23

REPOSITORIES: GEO

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Transcriptomic analysis of CD44+CD62L- CD8+ T cells purified from tumors and lymph nodes (LN) of whole-body irradiated or unirradiated MC38 tumor-bearing mice, by microarray

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