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MiRNA-seq of glioma patient tissues treated by DMSO or LY2109761

ABSTRACT: Glioma tissues from patients were cultured in complete DMEM and treated with either DMSO or LY2109761, an inhibitor of TGFBR2. Tissue blocks of TBD0207 and TBD0220 were subjected to miRNA-seq.

ORGANISM(S): Homo sapiens

PROVIDER: GSE111675 | GEO | 2021/03/07

REPOSITORIES: GEO

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RNA-seq of glioma patient tissues treated by DMSO or LY2109761

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Transcription profiling of human glioma cells treated with TGF-beta or an inhibitor of the TGF-beta Receptor I LY2109761

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Project description:Purpose: Evaluate transcriptional changes in glioma derived stem cells, U251, and normal human astrocytes following treatment with NH125, Tunicamycin, or 0.1% DMSO Methods: Glioma derived stem cells, U251 and Normal Human Astrocytes were plated in individual dishes and treated with either 2.5 micromolar NH125, 1.0 mcg/mL Tunicamycin, or 0.1% DMSO (vehicle) for twenty-four hours followed by total RNA extraction, library preparation and next generation sequencing Results: Using our analysis pipeline we mapped our sequence reads to the reference genome GRCh38. Following read count normalization and differential expression of NH125 and tunicamycin treated samples to vehicle treated controls we found that NH125 and tunicamycin treatment lead to activation of similar signalling pathways Conclusions: We present an optimized workflow for analysis of transcriptional changes in drug treated glioma derived stem cells, glioblastoma cells and normal human astrocytes

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