Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq of glioma patient-derived xenografts treated by DMSO or LY2109761

ABSTRACT: We employed the patient-derived xenografts (PDX) model to test the efficiency of LY2109761 in vivo. The drug was intraperitoneally administered, and the mice were sacrificed on the 31st day. The tumors were excised and subjected to RNA-seq. All groups had similar expression density distributions. Hierarchical clustering showed that the same processing groups had the closest distances.

ORGANISM(S): Homo sapiens

PROVIDER: GSE111673 | GEO | 2021/03/07

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

RNA-seq of glioma patient-derived xenografts treated by DMSO or LY2109761

Project description:RNA-seq of glioma patient-derived xenografts treated by DMSO or LY2109761

| PRJNA437856 | ENA

miRNA-seq of glioma patient tissues treated by DMSO or LY2109761

Project description:Glioma tissues from patients were cultured in complete DMEM and treated with either DMSO or LY2109761, an inhibitor of TGFBR2. Tissue blocks of TBD0207 and TBD0220 were subjected to miRNA-seq.

2021-03-07 | GSE111675 | GEO

RNA-seq of glioma patient tissues treated by DMSO or LY2109761

2021-03-07 | GSE111674 | GEO

Transcriptomic responses of hornyhead turbot (Pleuronichthys verticalis) to environmentally relevant doses of polybrominated diphenyl ethers or polychlorinated biphenyls

Project description:Hornyhead turbot (Pleuronichthys verticalis), a sentinel flatfish species, were intraperitoneally injected with environmentally relevant mixtures of polybrominated diphenyl ethers (PBDEs) or polychlorinated biphenyls (PCBs). After 96 h, fish were sacrificed and liver tissue was collected for gene expression analysis using a custom-designed microarray.

2020-10-01 | GSE151532 | GEO

Melanoma B16 transcriptome sequencing in C57BL16 mice under dacarbazine treatment

Project description:On day 7 after B16 melanoma cells transplantation, C57Bl6 mice with subcutaneous palpable tumors were randomly divided into 2 groups for experimental treatment with Dacarbazine. Group 1 «Control (PBS) », n=5, animals in this group were intraperitoneally injected with phosphate buffered saline in a volume of 250 µl. Group 2 «DTIC», n=5, animals in this group were intraperitoneally injected with a solution of Dacarbazine (DTIC) (Sigma-Aldrich, USA) in phosphate buffer at a concentration of 50 mg/kg of animal weight. Injections with PBS or DTIC were carried out three times on days 8, 10 and 12 after melanoma cell transplantation, on day 14, mice were sacrificed for further analysis of primary tumors and organs.

2024-02-10 | E-MTAB-13737 | biostudies-arrayexpress

miRNA-seq of glioma patient tissues treated by DMSO or LY2109761

Project description:miRNA-seq of glioma patient tissues treated by DMSO or LY2109761

| PRJNA437874 | ENA

RNA-seq of glioma patient tissues treated by DMSO or LY2109761

Project description:RNA-seq of glioma patient tissues treated by DMSO or LY2109761

| PRJNA437873 | ENA

Hepatic premalignant alterations triggered by human carcinogen aristolochic acid I in canines

Project description:Ten-month-old male beagle canines were purchased from the ANNIMO Science and Technology Ltd (Nanjing, China, Certificate No. SCXK (Su) 2010-0002), and maintained in a specific pathogen-free environment. Canines were randomly assigned to two groups (4 in each group) and received capsules with control filler or Aristolochic Acid I (AAI) filler (3 mg/kg/day, equivalent dose of mouse) for 10 days. Canines were sacrificed at 11 days after initiation of the treatment. Livers were excised immediately after sacrifice. Part of the livers were immediately snap-frozen in liquid nitrogen and kept at -80°C for total RNA isolation and microRNA microarray analysis.

2015-12-01 | GSE75474 | GEO

3D + LY vs. 3D culture of HUASMC

Project description:To study the impact of TGF signaling on the transcriptome of vascular smooth muscle cells, we cultured human umbilical artery smooth muscle cells as 3D aggregates in hanging drops for 48 hours. One group was treated with TGFβRI/II inhibitor LY2109761 (10 μM, additional 10 μM after 24 h), the other group with solvent (DMSO) as control. RNA was isolated from both groups after 48h

2019-12-16 | GSE133649 | GEO

Discovery of biomarkers in radioresistant MCF7R breast cancer xenografts

Project description:Radioresistance of tumors is not completely understood. Our previous studies have shown that MCF-7 breast cancer cell line exposed to 6 Gy and allowed to recover for 7 days (D7-6G) developed radio-resistance. In this study, we have tested the ability of these cells to form tumors in SCID mice and characterized these tumors by proteomic analyses. Untreated (MCF-C) and D7-6G cells (MCF-R) were injected s.c. in SCID mice and tumor growth monitored. On day 18, the mice were sacrificed and proteins were extracted from tumor tissues label free proteomic analyses was carried out by LC-MS.

2021-01-04 | PXD022506 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data