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24 weeks of HFD

ABSTRACT: Heart from dog at 24 weeks of HFD Keywords: repeat sample

ORGANISM(S): Canis lupus familiaris

PROVIDER: GSE1117 | GEO | 2004/03/30

SECONDARY ACCESSION(S): PRJNA87229

REPOSITORIES: GEO

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Project description:24 weeks of HFD

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Genome-wide expression profile of livers from mice fed HFD,SO-HFD or Viv chow [RNAseq]

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Project description:Gene expression in livers of male wild-type (WT) and OGG1-deficient (Ogg1-/-) mice fed either a chow diet or a high-fat diet (HFD) were examined. Mice were fed the diet for 10 weeks prior to tissue collection and were 22 weeks of age at the time of tissue collection. 24 Total samples were analyzed. We generated the following pairwise comparisons using GeneSifter: WT Chow vs Ogg1-/- Chow; WT HFD vs. Ogg1-/- HFD using t-test followed by Benjamini and Hochberg correction. An adjusted p-value less than 0.05 was considered to be statistically significant.

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Project description:To investigate the potential mechanism by which RECS1 regulate metabolic disorder, we treated control mice and RECS1 HKO mice with HFD for 8 weeks, and performed microarray to identify the expression pattern and the potential important molecules regulated by RECS1. We used microarrays to detect the global gene expression in the livers of control mice and RECS1 HKO mice after treatment with HFD for 8 weeks and identified distinct classes of altered genes in the livers of mice upon HFD compared .

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