Transcriptomics

Dataset Information

0

The m 6 A-methylase complex recruits TREX and regulates mRNA export.


ABSTRACT: N6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic mRNA. This modification has previously been shown to alter the export kinetics for mRNAs though the molecular details surrounding this phenomenon remain poorly understood. Here we show that the m6A complex (WTAP, KIAA1429, METTL3/14) drives recruitment of the TREX mRNA export complex onto m6A modified mRNAs and this process is essential for the efficient export of certain mRNAs. Depletion of the core m6A complex leads to loss of TREX from mRNAs which undergo the m6A modification. We show that TREX stimulates recruitment of the m6A reader protein YTHDC1 to the mRNP and the m6A complex influences the interaction of TREX with YTHDC1. We suggest that m6A acts as a surrogate for other TREX recruitment mechanisms such as splicing and 5’ capping, in long internal and final exons which may otherwise be devoid of this essential complex for mRNA export.

ORGANISM(S): Homo sapiens

PROVIDER: GSE111878 | GEO | 2018/10/03

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2014-09-18 | E-GEOD-58352 | biostudies-arrayexpress
2017-10-12 | GSE74397 | GEO
2013-02-15 | E-GEOD-40132 | biostudies-arrayexpress
2022-08-01 | GSE164353 | GEO
2016-09-07 | E-GEOD-78030 | biostudies-arrayexpress
2015-08-27 | E-GEOD-67431 | biostudies-arrayexpress
2023-03-20 | GSE210126 | GEO
2023-03-20 | GSE210125 | GEO
2014-09-18 | GSE58352 | GEO
2015-08-27 | GSE67431 | GEO