N6-methyladenosine-Mediated Nuclear Export of Messenger RNA
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ABSTRACT: N6-methyladenosine (m6A) is the most common internal modification in eukaryotic messenger RNA (mRNA). The effects of this reversible cheimcal modification are mediated in part by methyl-specific RNA binding protein 'readers' of the YTH family. In this study we present the function of YTHDC1 (YT521) in promoting the export of mRNA from the nucleus to the cytoplasm. Additionally, we identify a role for YTHDC1 in exon retention in mouse embryonic stem cells (mESCs).
ORGANISM(S): Mus musculus Homo sapiens
PROVIDER: GSE74397 | GEO | 2017/10/12
SECONDARY ACCESSION(S): PRJNA300279
REPOSITORIES: GEO
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