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Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE112107 | GEO | 2021/03/20

REPOSITORIES: GEO

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Procaspase 3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation

Project description:Purpose: To gain insights into the activity of Cyclin D1 in tumor maintenance, we developed a cancer cell-specific RNAi strategy to knock down its expression and analyze the outcome on gene expression profile of the entire tumor. Method: RAS/DNP53-driven tumor mRNA profiles were generated by RNA-Sequencing. Reads from RNA-Seq samples were mapped to the Mus musculus reference genome (MGSCv37) using Bowtie and TopHat. Transcript abundance and differential expression were called by Cufflinks. Results: Cyclin D1 knock down in RAS-G12V or MMTV-ErbB2-driven tumors leads to expression change of genes involved in developmental processes, but no significant change in apoptotic genes was recorded among the samples.

2020-04-11 | GSE63578 | GEO

Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation [in vivo]

Project description:Purpose: To gain insights into the activity of Cyclin D1 in tumor maintenance, we developed a specific RNAi strategy to knock down its expression and analyze the outcome on gene expression profile of the entire tumor. Method: MMTV-ErbB2 or RAS/DNP53-driven tumor mRNA profiles were generated by RNA-Sequencing. Results: Cyclin D1 knock down in RAS-G12V or MMTV-ErbB2-driven tumors leads to expression change of genes involved in developmental processes, but no change in FAS or FASL levels.

2021-03-20 | GSE112106 | GEO

Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation [in vitro]

Project description:Purpose: To gain insights into the activity of Cyclin D1 in tumor maintenance, we developed a specific RNAi strategy to knock down its expression and analyze the outcome on gene expression profile of RAS/DNP53-driven cancer cells (transformed MEFs). Cells were treated by RNAi or with Leptomycin B over night. Method: RAS/DNP53-transformed MEFs mRNA profiles were generated by RNA-Sequencing. Results: Cyclin D1 knock down in RAS-G12V-driven cancer cells leads to expression change of genes involved in developmental processes, but no change in FAS or FASL levels.

2021-03-20 | GSE112105 | GEO

Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation

Project description:Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation

| PRJNA439293 | ENA

Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation [in vivo]

Project description:Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation [in vivo]

| PRJNA439298 | ENA

Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation [in vitro]

Project description:Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation [in vitro]

| PRJNA439297 | ENA

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Project description:This SuperSeries is composed of the SubSeries listed below.

2009-12-20 | GSE18512 | GEO

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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