Transcript analysis of multi-locus sampled tumor tissue in patients with non-small cell lung cancer
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ABSTRACT: we investigated the spatial features of surgically-removed biopsies from multiple loci in tumor masses of 15 patients with non-small cell lung cancer (NSCLC). We observed that the immune microenvironment is highly spatial heterogeneous such that intra-tumoral regional variation is as large as inter-personal variation. While the local mutational burden was associated with local T cell clonal expansion, observed local anti-tumor cytotoxicity is strongly associated with local tumoral circumstance rather than TMB alone
ORGANISM(S): Homo sapiens
PROVIDER: GSE112996 | GEO | 2018/11/04
REPOSITORIES: GEO
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