Proteomics

Dataset Information

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Quantitative Proteomics by SWATH-MS reveals molecular differences among malignant and benign breast tumors in Mexican woman

ABSTRACT: Breast tumors are produced by an uncontrollable cell proliferation mechanism and can be classified as benign (TMB) or malignant (TMM). TMM or breast cancer is the neoplasia with the highest incidence and mortality in Mexican women. Over time, some types of TMB can transform into a TMM. However, the mechanisms involved in such processes remain elusive and limited studies have examined the molecular differences between TMB and TMM. Hence, the aim of this study was to evaluate and compare the proteomic profile of TMB (n = 10) and TMM (n = 6) of Mexican women.

INSTRUMENT(S): TripleTOF 5600+

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Breast Cancer Cell

SUBMITTER: Vareska Zárate  

LAB HEAD: Aldo Moreno Ulloa

PROVIDER: PXD019334 | Pride | 2024-10-22

REPOSITORIES: Pride

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Action DRS
20181011_IDA_CM_POOL_1_2_3_4_C18_15cm_150min_5uLmin_5-30B_4uLiny_0.05_10_.group Other
20181011_IDA_CM_POOL_1_2_3_4_C18_15cm_150min_5uLmin_5-30B_4uLiny_0.05_10__100p_13RT_updateRT.txt Txt
20181011_IDA_CM_POOL_1_2_3_4_C18_15cm_150min_5uLmin_5-30B_4uLiny_0.05_10__MGFPeaklist.mgf Mgf
20181011_SWATH_17_CM_C18_15cm_150min_5uLmin_5-30B_4uLiny.wiff Wiff
20181011_SWATH_17_CM_C18_15cm_150min_5uLmin_5-30B_4uLiny.wiff.scan Wiff
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Publications

The distinction between noncancerous and cancerous breast tissues is challenging in clinical settings, and discovering new proteomics-based biomarkers remains underexplored. Through a pilot proteomic study (discovery cohort), we aimed to identify a protein signature indicative of breast cancer for subsequent validation using six published proteomics/transcriptomics data sets (validation cohorts). Sequential window acquisition of all theoretical (SWATH)-based mass spectrometry revealed 370 differ  ...[more]

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