Proteomics

Dataset Information

0

Quantitative Proteomics by SWATH-MS reveals molecular differences among malignant and benign breast tumors in Mexican woman

ABSTRACT: Breast tumors are produced by an uncontrollable cell proliferation mechanism and can be classified as benign (TMB) or malignant (TMM). TMM or breast cancer is the neoplasia with the highest incidence and mortality in Mexican women. Over time, some types of TMB can transform into a TMM. However, the mechanisms involved in such processes remain elusive and limited studies have examined the molecular differences between TMB and TMM. Hence, the aim of this study was to evaluate and compare the proteomic profile of TMB (n = 10) and TMM (n = 6) of Mexican women.

INSTRUMENT(S): TripleTOF 5600+

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Breast Cancer Cell

SUBMITTER: Vareska Zárate  

LAB HEAD: Aldo Moreno Ulloa

PROVIDER: PXD019334 | Pride | 2024-10-22

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
20181011_IDA_CM_POOL_1_2_3_4_C18_15cm_150min_5uLmin_5-30B_4uLiny_0.05_10_.group Other
20181011_IDA_CM_POOL_1_2_3_4_C18_15cm_150min_5uLmin_5-30B_4uLiny_0.05_10__100p_13RT_updateRT.txt Txt
20181011_IDA_CM_POOL_1_2_3_4_C18_15cm_150min_5uLmin_5-30B_4uLiny_0.05_10__MGFPeaklist.mgf Mgf
20181011_SWATH_17_CM_C18_15cm_150min_5uLmin_5-30B_4uLiny.wiff Wiff
20181011_SWATH_17_CM_C18_15cm_150min_5uLmin_5-30B_4uLiny.wiff.scan Wiff
Items per page:
1 - 5 of 38
altmetric image

Publications

The distinction between noncancerous and cancerous breast tissues is challenging in clinical settings, and discovering new proteomics-based biomarkers remains underexplored. Through a pilot proteomic study (discovery cohort), we aimed to identify a protein signature indicative of breast cancer for subsequent validation using six published proteomics/transcriptomics data sets (validation cohorts). Sequential window acquisition of all theoretical (SWATH)-based mass spectrometry revealed 370 differ  ...[more]

Similar Datasets

Proteomics Integrated lipidomics and proteomics reveal cardiolipin remodelling by upregulation of HADHA and indirectly by ELOVL5 in pancreatic cancer stem cells
2021-09-09 | PXD023069 | Pride
Proteomics A comprehensive CHO SWATH-MS spectral library for accurate quantitative profiling of 10k proteins
2020-07-20 | PXD016047 | Pride
Proteomics Sulfide Regulates Autophagy by Reversible Persulfidation of the Cysteine Protease ATG4
2020-12-14 | PXD019802 | Pride
Proteomics Bovine Coronary Artery Endothelial Cells-SWATH Proteomics
2022-08-11 | PXD013643 | Pride
Proteomics,Multiomics SWATH-MS proteomic analysis of primary human keratinocytes exposed to Cannabidiol
2019-10-16 | PXD013956 | Pride
Proteomics SWATH proteomic profiling of prostate cancer cells identifies NUSAP1 as a biomarker of response to Galiellalactone
2019-01-14 | PXD010993 | Pride
Proteomics SWATH quantitative proteomics and cellular assays show in vitro anticancer activity of ARA- and DHA-based monoacylglycerols in colorectal cancer cells
2022-01-28 | PXD009979 | Pride
Proteomics Cryopreservation and egg yolk medium alter the proteome of ram spermatozoa
2018-04-26 | PXD009331 | Pride
Proteomics Proteomic analysis of extracellular vesicles derived from platelet concentrates treated with Mirasol® identifies biomarkers of platelet storage lesion
2022-09-30 | PXD014694 | Pride
Proteomics The Akirin2 regulome and interactome reveal gene/protein targets, candidate functional complements and role in epigenetic regulation
2021-09-09 | PXD022073 | Pride