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Dazl HITS-CLIP on 25dpp C57BL/6 mouse testes

ABSTRACT: The autosomal gene Dazl is a member of highly conservative DAZ family, all of which contains a RNA binding domain and expresses in germ cells. In mice, Dazl plays an essential role in germ cell development, germ cell lost in Dazl knockout mouse on pure C57BL/6 strain background. Here we use HITS-CLIP to globally characterize the genome-wide target RNA of Dazl in mouse testes. Sequencing data provides large quantities of clues to help us to get close to the truth of Dazl function. We find over 1700 RNAs are bind by Dazl mainly at 3’UTR and the genes associated with transcription, RNA splicing and reproductive cellular process are enriched significantly.

ORGANISM(S): Mus musculus

PROVIDER: GSE113710 | GEO | 2019/10/09

REPOSITORIES: GEO

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RNA-seq of 10dpp wild type and Dazl SKO mouse testes

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Project description:Dazl HITS-CLIP on 25dpp C57BL/6 mouse testes

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