Transcriptomics

Dataset Information

0

Identification and functional analysis of a potential key lncRNA in aged mice with postoperative cognitive dysfunction


ABSTRACT: Postoperative cognitive decline (POCD) is emerging as a significant complication of surgery in elderly patients. However, the molecular mechanisms of POCD are elusive. Here we applied microarray analyses to identify long non-coding RNA (lncRNA) and mRNA expression profiles in hippocampal tissues from a mouse model of POCD and control mice. A total of 869 lncRNAs and 690 mRNAs were differentially expressed between POCD and control mice. Subsequently, six dysregulated lncRNAs and six mRNAs were confirmed via quantitative real-time polymerase chain reaction (qRT-PCR) in 8 paired samples. Then, Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to probe the vital functions of dysregulated genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE113738 | GEO | 2019/08/20

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-07-14 | GSE147277 | GEO
2017-02-20 | GSE95070 | GEO
2022-12-09 | GSE215410 | GEO
2021-06-09 | GSE163943 | GEO
2021-05-31 | E-MTAB-10510 | biostudies-arrayexpress
| PRJNA613660 | ENA
2021-06-23 | GSE174412 | GEO
2021-06-23 | GSE174411 | GEO
2021-06-23 | GSE174410 | GEO
2015-02-13 | E-MTAB-3187 | biostudies-arrayexpress