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Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells

ABSTRACT: The human pluripotent stem cells cultured on Low-adhesion substrates formed two morphologically different subtypes (Monolayer and Domed). The dome-like cells showed higher proliferation capacity and KLF4/5 expression than the monolayer cells. A serum response factor based regulatory double loop was proposed to explain how cell-matrix adhesion mediates the interaction between cell morphology and pluripotency genes

ORGANISM(S): Homo sapiens

PROVIDER: GSE115256 | GEO | 2018/06/11

REPOSITORIES: GEO

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