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Inflammation-produced TNFα protects hematopoietic stem cells from necroptosis and promotes hematopoietic regeneration

ABSTRACT: To gain molecular insights into the differential effect of TNFα between hematopoietic stem cells (HSC) and downstream myeloid progenitors, we performed RNA-sequencing analyses of HSCs and granulocyte-macrophage progenitors (GMP) treated with TNFα both ex vivo and in vivo.

ORGANISM(S): Mus musculus

PROVIDER: GSE115403 | GEO | 2019/07/01

REPOSITORIES: GEO

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Inflammation-produced TNFα protects hematopoietic stem cells from necroptosis and promotes hematopoietic regeneration

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