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Transcriptome analysis of OGT-sufficient and OGT-deficient regulatory T (Treg) cells

ABSTRACT: To gain comprehensive insight into the OGT-dependent transcriptional program in Treg cells, we performed RNA-sequencing of isolated YFP+ Treg cells from Foxp3YFP-Cre/wtOgtwt/fl and healthy Foxp3YFP-Cre/wtOgtfl/fl females to avoid secondary changes in gene expression caused by inflammation. We were able to identify 269 differentially expressed genes including 154 downregulated and 115 upregulated with p values less than 0.01, OGT-deficient Treg cells had impaired suppressive function and attenuated IL2/STAT5 signaling pathway.

ORGANISM(S): Mus musculus

PROVIDER: GSE116758 | GEO | 2018/12/21

REPOSITORIES: GEO

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