Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Role of ProQ in Salmonella virulence

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 Homo sapiens

PROVIDER: GSE117256 | GEO | 2018/11/28

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Role of putative RNA-binding proteins in Campylobacter jejuni gene expression and virulence

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2012-12-31 | E-GEOD-35137 | biostudies-arrayexpress

Role of microRNAs in the interaction between Salmonella and the host cell

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-07-18 | E-GEOD-53281 | biostudies-arrayexpress

Role of stpA in Salmonella typhimurium

Project description:This SuperSeries is composed of the SubSeries listed below.

2009-10-28 | GSE18452 | GEO

Host succinate is a signal for activation of Salmonella virulence during intracellular infection

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-10-19 | GSE139208 | GEO

Role of ProQ in Salmonella virulence - in vitro

Project description:FinO-domain proteins such as ProQ of the model pathogen Salmonella enterica have emerged as a new class of major RNA-binding proteins in bacteria. ProQ has been shown to target hundreds of transcripts including mRNAs from many virulence regions but its role, if any, in bacterial pathogenesis has not been studied. Here, using a Dual RNA-seq approach to profile ProQ-dependent gene expression changes as Salmonella infects human cells, we reveal dysregulation of bacterial motility, chemotaxis and virulence genes which is accompanied by altered mitogen-activated protein kinase signaling in the host. Comparison with Hfq, Salmonella’s other major RNA chaperone, reinforces the notion that these two global RNA binding proteins work in parallel to ensure full virulence. Of newly discovered infection-associated ProQ-bound small noncoding RNAs, we show that STnc540 represses a virulence-related magnesium transporter mRNA in a ProQ-dependent manner. Together, this comprehensive study uncovers the relevance of ProQ for Salmonella infection and highlights the importance of RNA-binding proteins in regulating bacterial virulence programs.

2018-11-28 | GSE117255 | GEO

Role of ProQ in Salmonella virulence - pulse expression

2018-11-28 | GSE117252 | GEO

Aryl hydrocarbon receptor senses bacterial pigmented virulence factors and orchestrates anti-bacterial defenses

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-01-01 | E-GEOD-48133 | biostudies-arrayexpress

Yap role in intestine

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2012-11-29 | E-GEOD-41509 | biostudies-arrayexpress

Intestinal Salmonella Typhimurium infection leads to miR-29a induced Caveolin 2 regulation

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-06-25 | E-GEOD-40805 | biostudies-arrayexpress