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Distinct microglial transcriptional responses during opioid exposure or neuropathic pain

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Rattus norvegicus

PROVIDER: GSE117321 | GEO | 2022/01/03

REPOSITORIES: GEO

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Distinct microglial transcriptional responses during opioid exposure or neuropathic pain [mouse]

Project description:In settings of heightened pain sensitivity, such as following peripheral nerve injury (PNI) or opioid-induced hyperalgesia (OIH), microglia take on an activated phenotype. Functional studies have suggested that microglia activated by PNI or chronic opioids then engage common mechanisms to facilitate pain. Here we conducted RNA sequencing of acutely isolated spinal cord microglia to comprehensively interrogate commonality between PNI and OIH. By combining our results with meta-analysis of published datasets, we identify transcriptional signatures of microglial reactivity that differ between PNI models over time, opioid exposure, or CNS pathology, despite similar histological outcomes. Collectively, these results reveal a discrepancy between histological markers of activation and transcriptional response, and provide a resource of pain-associated microglial transcriptomes that caution against a universal signature of microglia activation.

2022-01-03 | GSE117320 | GEO

Distinct microglial transcriptional responses during opioid exposure or neuropathic pain [rat]

2022-01-03 | GSE117319 | GEO