Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

ABSTRACT: RNA expression in CD4 positive naïve and dendritic cell-activated T cells

ORGANISM(S): Mus musculus

PROVIDER: GSE120277 | GEO | 2020/11/24

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [ChIP]

Project description:Epigenetic profile of CD4 positive naïve and dendritic cell-activated T cells

2020-11-24 | GSE141723 | GEO

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [12hRNA]

Project description:RNA expression in CD4 positive naïve and dendritic cell-activated T cells

2020-11-24 | GSE141722 | GEO

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-11-24 | GSE141724 | GEO

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

Project description:Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

| PRJNA492388 | ENA

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

Project description:Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

| PRJNA594519 | ENA

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [12hRNA]

Project description:Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [12hRNA]

| PRJNA594525 | ENA

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [ChIP]

Project description:Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [ChIP]

| PRJNA594524 | ENA

Memory-phenotype CD4+ T cells spontaneously generated under steady-state conditions exert innate TH1-like effector function.

Project description:Conventional CD4+ T cells are composed of naïve, pathogen-specific memory, and pathogen-independent memory-phenotype (MP) cells under steady state. Naïve and pathogen-specific memory cells play key roles in adaptive immunity, whereas the homeostatic mechanisms regulating the generation of MP cells and their biological functions are unclear. We show that MP cells are autonomously generated from peripheral naïve cells in the absence of infectious stimulation in a T cell receptor (TCR)- and CD28-dependent manner. We further demonstrate that MP cells contain a T-bethi subpopulation that is continuously generated by environmental interleukin-12 (IL-12) and rapidly produces interferon-γ (IFN-γ) in response to IL-12 in the absence of pathogen recognition. These cells can provide nonspecific host resistance against Toxoplasma gondii infection while enhancing the adaptive CD4+ T cell responses. Together, these findings reveal that MP cells are continuously generated from naïve precursors and have a previously undescribed innate immune function by which they produce an early, T helper cell type 1 (TH1)-like protective response against pathogens.

| S-EPMC5568832 | biostudies-literature

Short-Lived Antigen Recognition but Not Viral Infection at a Defined Checkpoint Programs Effector CD4 T Cells To Become Protective Memory.

Project description:Although memory CD4 T cells are critical for effective immunity to pathogens, the mechanisms underlying their generation are still poorly defined. We find that following murine influenza infection, most effector CD4 T cells undergo apoptosis unless they encounter cognate Ag at a defined stage near the peak of effector generation. Ag recognition at this memory checkpoint blocks default apoptosis and programs their transition to long-lived memory. Strikingly, we find that viral infection is not required, because memory formation can be restored by the addition of short-lived, Ag-pulsed APC at this checkpoint. The resulting memory CD4 T cells express an enhanced memory phenotype, have increased cytokine production, and provide protection against lethal influenza infection. Finally, we find that memory CD4 T cell formation following cold-adapted influenza vaccination is boosted when Ag is administered during this checkpoint. These findings imply that persistence of viral Ag presentation into the effector phase is the key factor that determines the efficiency of memory generation. We also suggest that administering Ag at this checkpoint may improve vaccine efficacy.

| S-EPMC5113829 | biostudies-literature

A Two-Step Process of Effector Programming Governs CD4<sup>+</sup> T Cell Fate Determination Induced by Antigenic Activation in the Steady State.

Project description:Various processes induce and maintain immune tolerance, but effector T cells still arise under minimal perturbations of homeostasis through unclear mechanisms. We report that, contrary to the model postulating primarily tolerogenic mechanisms initiated under homeostatic conditions, effector programming is an integral part of T cell fate determination induced by antigenic activation in the steady state. This effector programming depends on a two-step process starting with induction of effector precursors that express Hopx and are imprinted with multiple instructions for their subsequent terminal effector differentiation. Such molecular circuits advancing specific terminal effector differentiation upon re-stimulation include programmed expression of interferon-γ, whose production then promotes expression of T-bet in the precursors. We further show that effector programming coincides with regulatory conversion among T cells sharing the same antigen specificity. However, conventional type 2 dendritic cells (cDC2) and T cell functions of mammalian target of rapamycin complex 1 (mTORC1) increase effector precursor induction while decreasing the proportion of T cells that can become peripheral Foxp3+ regulatory T (pTreg) cells.

| S-EPMC7714042 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data