Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

ABSTRACT: Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

PROVIDER: PRJNA492388 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7888230.fastq.gz	Fastqsanger.gz
	SRR7888240.fastq.gz	Fastqsanger.gz
	SRR7888231.fastq.gz	Fastqsanger.gz
	SRR7888232.fastq.gz	Fastqsanger.gz
	SRR7888223.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

Project description:Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

| PRJNA594519 | ENA

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [ChIP]

Project description:Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [ChIP]

| PRJNA594524 | ENA

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [12hRNA]

Project description:Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [12hRNA]

| PRJNA594525 | ENA

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

Project description:RNA expression in CD4 positive naïve and dendritic cell-activated T cells

2020-11-24 | GSE120277 | GEO

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-11-24 | GSE141724 | GEO

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [ChIP]

Project description:Epigenetic profile of CD4 positive naïve and dendritic cell-activated T cells

2020-11-24 | GSE141723 | GEO

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [12hRNA]

Project description:RNA expression in CD4 positive naïve and dendritic cell-activated T cells

2020-11-24 | GSE141722 | GEO

Effector differentiation downstream of lineage commitment in ILC1 is driven by Hobit across tissues.

Project description:Innate lymphoid cells (ILCs) mediate early immunity against infection and participate in tissue inflammation and homeostasis. It is unclear how ILCs acquire effector function, and whether these mechanisms differ between organs. Through multiplexed single-cell mRNA-sequencing we identified cKit+CD127hiTCF-1hi early differentiation stages of T-bet+ ILC1. These cells were present across different organs and had the potential to mature towards CD127intTCF-1int and CD127-TCF-1- ILC1. Paralleling a gradual loss of TCF-1, differentiating ILC1 forfeited their expansion potential while increasing expression of effector molecules, reminiscent of T cell differentiation in secondary lymphoid organs. The transcription factor Hobit was induced in TCF-1hi ILC1s and was required for their effector differentiation. These findings reveal sequential mechanisms of ILC1 lineage commitment and ILC1 effector differentiation that are conserved across tissues. Our analyses suggest that ILC1 emerge as TCF-1hi cells in the periphery and acquire a spectrum of organ-specific effector phenotypes through a uniform Hobit-dependent differentiation pathway driven by local cues.

2021-07-27 | GSE163452 | GEO

Zfp335 establishes neonatal immune tolerance through safeguarding effector Treg lineage commitment and maintenance

Project description:Zfp335 establishes neonatal immune tolerance through safeguarding effector Treg lineage commitment and maintenance

| PRJNA781244 | ENA

Zfp335 establishes neonatal immune tolerance through safeguarding effector Treg lineage commitment and maintenance.

Project description:Zfp335 establishes neonatal immune tolerance through safeguarding effector Treg lineage commitment and maintenance.

| PRJNA781461 | ENA