Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE141724 | GEO | 2020/11/24

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

Project description:RNA expression in CD4 positive naïve and dendritic cell-activated T cells

2020-11-24 | GSE120277 | GEO

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [ChIP]

Project description:Epigenetic profile of CD4 positive naïve and dendritic cell-activated T cells

2020-11-24 | GSE141723 | GEO

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [12hRNA]

Project description:RNA expression in CD4 positive naïve and dendritic cell-activated T cells

2020-11-24 | GSE141722 | GEO

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

Project description:Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

| PRJNA594519 | ENA

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

Project description:Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation

| PRJNA492388 | ENA

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [ChIP]

Project description:Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [ChIP]

| PRJNA594524 | ENA

Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [12hRNA]

Project description:Early commitment in the steady state programs antigen specific CD4+ T cells for subsequent effector differentiation [12hRNA]

| PRJNA594525 | ENA

Memory-phenotype CD4+ T cells spontaneously generated under steady-state conditions exert innate TH1-like effector function.

Project description:Conventional CD4+ T cells are composed of naïve, pathogen-specific memory, and pathogen-independent memory-phenotype (MP) cells under steady state. Naïve and pathogen-specific memory cells play key roles in adaptive immunity, whereas the homeostatic mechanisms regulating the generation of MP cells and their biological functions are unclear. We show that MP cells are autonomously generated from peripheral naïve cells in the absence of infectious stimulation in a T cell receptor (TCR)- and CD28-dependent manner. We further demonstrate that MP cells contain a T-bethi subpopulation that is continuously generated by environmental interleukin-12 (IL-12) and rapidly produces interferon-γ (IFN-γ) in response to IL-12 in the absence of pathogen recognition. These cells can provide nonspecific host resistance against Toxoplasma gondii infection while enhancing the adaptive CD4+ T cell responses. Together, these findings reveal that MP cells are continuously generated from naïve precursors and have a previously undescribed innate immune function by which they produce an early, T helper cell type 1 (TH1)-like protective response against pathogens.

| S-EPMC5568832 | biostudies-literature

Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.

Project description:CD4+ T lymphocytes consist of naïve, antigen-specific memory, and memory-phenotype (MP) cell compartments at homeostasis. We recently showed that MP cells exert innate-like effector function during host defense, but whether MP CD4+ T cells are functionally heterogeneous and, if so, what signals specify the differentiation of MP cell subpopulations under homeostatic conditions is still unclear. Here we characterize MP lymphocytes as consisting of T-bethigh, T-betlow, and T-bet- subsets, with innate, Th1-like effector activity exclusively associated with T-bethigh cells. We further show that the latter population depends on IL-12 produced by CD8?+ type 1 dendritic cells (DC1) for its differentiation. Finally, our data demonstrate that this tonic IL-12 production requires TLR-MyD88 signaling independent of foreign agonists, and is further enhanced by CD40-CD40L interactions between DC1 and CD4+ T lymphocytes. We propose that optimal differentiation of T-bethigh MP lymphocytes at homeostasis is driven by self-recognition signals at both the DC and Tcell levels.

| S-EPMC7338451 | biostudies-literature

Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes.

Project description:It is thought that monocytes rapidly differentiate to macrophages or dendritic cells (DCs) upon leaving blood. Here we have shown that Ly-6C? monocytes constitutively trafficked into skin, lung, and lymph nodes (LNs). Entry was unaffected in gnotobiotic mice. Monocytes in resting lung and LN had similar gene expression profiles to blood monocytes but elevated transcripts of a limited number of genes including cyclo-oxygenase-2 (COX-2) and major histocompatibility complex class II (MHCII), induced by monocyte interaction with endothelium. Parabiosis, bromodoxyuridine (BrdU) pulse-chase analysis, and intranasal instillation of tracers indicated that instead of contributing to resident macrophages in the lung, recruited endogenous monocytes acquired antigen for carriage to draining LNs, a function redundant with DCs though differentiation to DCs did not occur. Thus, monocytes can enter steady-state nonlymphoid organs and recirculate to LNs without differentiation to macrophages or DCs, revising a long-held view that monocytes become tissue-resident macrophages by default.

| S-EPMC3820017 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data