Age-dependent changes in transcription factor FOXO targeting in Drosophila melanogaster
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ABSTRACT: FOXO transcription factors control numerous pathways involving metabolism, stress response, and longevity. Although direct targets of FOXO have been reported in various long-lived mutants and under stress conditions, no studies have investigated how normal aging impacts the cellular activity of FOXO. In this study, we compared genome wide dFOXO-bound sites in young and aged wild-type flies kept under normal feeding conditions to evaluate the dynamics of FOXO gene targeting during aging. Our results provide a new insight into FOXO chromatin targeting under a normal aging model and highlight the diverse regulatory mechanisms for FOXO transcriptional activity that are currently less understood.
ORGANISM(S): Drosophila melanogaster
PROVIDER: GSE121102 | GEO | 2019/04/25
REPOSITORIES: GEO
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