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A peninsular structure coordinates asynchronous differentiation with morphogenesis to generate pancreatic islets [bulk vs buds]

ABSTRACT: This RNA-seq data is an integral part of a manuscript with the above title. To better characterize the buds appearing on the surface of the spheroidal clusters during the directed differentiation of HUES8 human embryonic stem cells to pancreatic endocrine cells, we performed bulk RNA-sequencing of the buds versus the bulks. Our results indicate that the buds indeed consist of pancreatic endocrine cells, illustrating our ability to recapitulate in vitro our in vivo observations of pancreatic islets forming via peninsular intermediates. See manuscript for more information.

ORGANISM(S): Homo sapiens

PROVIDER: GSE121679 | GEO | 2018/10/24

REPOSITORIES: GEO

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A peninsular structure coordinates asynchronous differentiation with morphogenesis to generate pancreatic islets

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