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Surface PEGylation Suppresses Pulmonary Effects of CuO in Allergen-Induced Lung Inflammation

ABSTRACT: The objective of the study was to investigate how pristine CuO modulates allergic lung inflammation and whether surface modifications can influence its reactivity. CuO materials exacerbated the existing allergic airway inflammation by eliciting dramatic pulmonary neutrophilia. Transcriptomic analysis showed that CuO, CuO COOH and CuO NH3 commonly enriched neutrophil-related biological processes in lungs with and without the pre-existing condition. In contrast, CuO PEG had a significantly lower potential in triggering pulmonary changes revealing that surface PEGylation suppresses the effects triggered by the pristine material.

ORGANISM(S): Mus musculus

PROVIDER: GSE122197 | GEO | 2019/07/06

REPOSITORIES: GEO

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Surface PEGylation Suppresses Pulmonary Effects of CuO in Allergen-Induced Lung Inflammation

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