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The in vitro effect of orexin A on the porcine myometrial transcriptomic profile during early-implantation period

ABSTRACT: Orexins belong to the group of metabolism regulating factors connected mainly with the nervous system. Both biologically active neuropeptides, orexin A (OXA) and orexin B (OXB) are products of the proteolytic cleavage of common 130 amino-acid precursor – prepro-orexin (PPO). In the reproductive system orexins has been found to act not only on the endocrine, but also auto- and paracrine manner. In the present study we focused on the effect of OXA treatment on the global gene expression in the porcine myometrium during the most dynamic phase of the early pregnancy – the implantation period (days 15 to 16 of gestation).

ORGANISM(S): Sus scrofa Sus scrofa domesticus

PROVIDER: GSE122310 | GEO | 2018/11/09

REPOSITORIES: GEO

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The in vitro influence of orexin B on the porcine myometrium on days 15 to 16 of gestation.

Project description:Orexin A (OXA) and orexin B (OXB) are hypothalamic-derived peptides that participate in the regulation of energy metabolism, food intake and reproductive function by influencing the hypothalamic-pituitary-ovarian axis. Orexins are also produced in the endometrium, myometrium and placenta, which suggests that they could act as a link between energy metabolism and the reproductive system. The aim of this study was to explore the influence of orexin B on global gene expression in the porcine myometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).

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The in vitro influence of orexin B on the porcine endometrium on days 15 to 16 of gestation.

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Gene profiling within the orexin-producing neurons

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The in vitro effect of orexin A on the porcine myometrial transcriptomic profile during early-implantation period

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Orexin/Hypocretin Receptor 2 Signaling in MCH Neurons Regulates REM sleep and Insulin Sensitivity

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