Comparative analysis of the gene expression profiles of M.tuberculosis espR (Rv3849) transposon and knockout mutants
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ABSTRACT: Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) is a key regulator of ESX-1. EspR activates transcription of an operon that includes three ESX-1 components, Rv3616c-Rv3614c, whose expression in turn promotes secretion of ESX-1 substrates. Keywords: Strain comparison
ORGANISM(S): Mycobacterium tuberculosis
PROVIDER: GSE12381 | GEO | 2008/08/08
SECONDARY ACCESSION(S): PRJNA113869
REPOSITORIES: GEO
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