Ontology highlight
ABSTRACT:
ORGANISM(S): Mycobacterium tuberculosis
SUBMITTER: Jeffery Cox
PROVIDER: E-GEOD-12381 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Raghavan Sridharan S Manzanillo Paolo P Chan Kaman K Dovey Cole C Cox Jeffery S JS
Nature 20080801 7205
Bacterial pathogens trigger specialized virulence factor secretion systems on encountering host cells. The ESX-1 protein secretion system of Mycobacterium tuberculosis-the causative agent of the human disease tuberculosis-delivers bacterial proteins into host cells during infection and is critical for virulence, but how it is regulated is unknown. Here we show that EspR (also known as Rv3849) is a key regulator of ESX-1 that is required for secretion and virulence in mice. EspR activates transcr ...[more]