Influence of type I Interferons on function of splenic conventional dendritic cells.
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ABSTRACT: Type I Interferons encompasses a large family of closely related cytokines comprising of at least 13 IFN-α isotypes and single IFN-β. Both IFN-α and IFN-β exert their activity through a common receptor IFNAR. Type I Interferons have broad regulatory effects and various subtypes of dendritic cells are influenced by this cytokines. In our study we asked question whether the low, constitutive levels of type I Interferons produced under steady state conditions are important for proper function of splenic conventional dendritic cells.
ORGANISM(S): Mus musculus
PROVIDER: GSE12392 | GEO | 2009/07/07
SECONDARY ACCESSION(S): PRJNA113147
REPOSITORIES: GEO
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