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Genome-wide maps of DNA methylation and gene expression for multiple regions within a breast tumor

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE124033 | GEO | 2020/01/01

REPOSITORIES: GEO

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Genome-wide maps of DNA methylation and gene expression for multiple regions within a breast tumor [RRBS]

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Genome-wide maps of DNA methylation and gene expression for multiple regions within a breast tumor

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Breast Cancer: Multiple Subtypes within a Tumor?

Project description:Breast cancer is a heterogeneous disease, and stratification of tumors is paramount to achieve better clinical outcomes. While it is common to stratify and treat breast tumors as a single entity, insights from studies on intratumoral heterogeneity and cancer stem cells raise the possibility that multiple breast cancer subtypes may coexist within a tumor. A role for plasticity in driving dynamic conversions between breast cancer subtypes is proposed, and the clinical implications include a need for combinatorial therapeutic strategies that account for the discrete disease entities and their plasticity. Accordingly, the advent of single-cell technologies will be crucial in enabling the diagnosis and stratification of distinct disease subtypes down to the cellular level.

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