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Hypothalamus of db/db mice treated with celastrol and DMSO

ABSTRACT: Given that celastrol?s leptin-sensitizing effect requires both high levels of circulating leptin and intact leptin receptor signaling, we analyzed the effect of celastrol on hypothalamic gene expression profile of db/db mice, which have high circulating levels of leptin, but lack intact leptin receptor signaling. This analysis will be serving as negative control for DIO mice analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE124355 | GEO | 2018/12/27

REPOSITORIES: GEO

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