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RNA-seq from monocytes derived dendritic cells (MoDC) samples purified from spleen of C57BL/6 mice to evaluate their gene expression during Plasmodium berguei ANKA (PbA) infection

ABSTRACT: Dendritic cells have an important role in immune surveillance. After being exposed to microbial components, they migrate to secondary lymphoid organs and activate T lymphocytes. During mouse model malaria, splenic inflammatory monocytes differentiate into monocyte-derived dendritic cells (MO-DCs), which are CD11b+F4/80+CD11c+MHCIIhighDC-SIGNhighLy6c+ and express high levels of CCR5, CXCL9 and CXCL10 (CCR5+CXCL9/10+ MO-DCs). We intend to use these malaria-induced splenic MO-DCs gene expression data to understand more about the migratory route taken by these cells as well the most important genes/pathways involved on this cell differentiation in the spleen, allowing them to migrate to the brain where they develop an important role in cerebral malaria.

ORGANISM(S): Mus musculus

PROVIDER: GSE126381 | GEO | 2020/07/31

REPOSITORIES: GEO

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