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Single cell changes in postnatal P7 and in adult cardiac endothelium upon VEGF-B overexpression

ABSTRACT: We have previously reported that mice expressing a cardiomyocyte-specific αMHC-VEGF-B transgene in the heart show a clear expansion of the coronary vasculature and cardiac hypertrophy, without significant changes in heart function. As a therapeutic way of administrating VEGF-B protective effects, we show that AAV-VEGF-B induces the proliferation of endothelial cells (EC). All the samples were analyzed using the Chromium Single-cell 3'RNA-sequencing system.

ORGANISM(S): Mus musculus

PROVIDER: GSE128509 | GEO | 2022/03/15

REPOSITORIES: GEO

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