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MSCs in co-culture with CLL cells acquire a CAF-like phenotype.

ABSTRACT: Human primary mesenchymal stromal cells (MSCs) were either left untreated, treated with 3 µg/ml/day GRN, or co-cultured with CD19-sorted CLL cells of two different patients for 5 days. Gene expression of the MSCs was quantified using an Illumina HumanHT-12 v4 Expression BeadChip. Thereby, genes assigned to 454 Illumina probes were identified to be significantly altered by CLL co-culture compared to control MSCs cultured alone (analysed dataset provided). MSCs in co-culture with CLL cells resembled a CAF-like phenotype. There were no significant transcriptional changes detected in GRN treated compared to untreated MSCs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE129108 | GEO | 2019/06/20

REPOSITORIES: GEO

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