Genomics

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Small RNA sequencing of plasma cells of multiple myeloma patients with extramedullary disease


ABSTRACT: Background: Extramedullary disease (EM) in multiple myeloma (MM) is defined by escape of malignant plasma cells out of the bone marrow. The mechanisms of extramedullary spread are not well understood. MicroRNAs (miRNA) were proven to be involved in the pathogenesis of MM; nevertheless, there is a lack of knowledge about their role in EM. Methods: Using NGS analysis, we identified ten differentially expressed miRNA in plasma cells of MM versus EM patients. We performed qPCR in validation phase, using TaqMan Advanced MiRNA Assays. Results: In this study, we identified 10 miRNAs differentially expressed between MM and EM patiens.

ORGANISM(S): Homo sapiens

PROVIDER: GSE129918 | GEO | 2022/12/14

REPOSITORIES: GEO

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