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Gene expression changes in astrocytes by pulsed radiofrequency: a possible mechanism of neuropathic pain improvement

ABSTRACT: We investigated genomic effects of pulsed radiofrequency (PRF) on mouse cultured astrocyte cell line, C8D1A cells, using microarray analysis. PRF increased 2,431 genes and decreased 209 genes. Among these genes, 435 genes were upregulated with more than 10-fold, 89 genes with more than 30-fold, while there was no gene with 10-fold decrease. From the gene ontology analysis using the list of 10-fold upregulated genes, PRF treatment activated immune response. From pathway analysis using Kyoto Encyclopedia of Gene and Genomes using the same list, 7 pathways related with neuropathic pain were detected.

ORGANISM(S): Mus musculus

PROVIDER: GSE130755 | GEO | 2019/05/31

REPOSITORIES: GEO

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