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Transcriptomic profiling of zebrafish livers with nAtf6 overexpression at collected at 78 and 120 hpf

ABSTRACT: Activting transcription factor 6 (Atf6) is one of three main mediators of the Unfolded Protein Response and it gets cleaved cleaved in the Golgi and its N-terminal consisting of the bZip domain translocates into the nucleus to generate a transcriptional response (nAtf6). This study carries out RNAseq on an established transgenic overexpression of nAtf6 in zebrafish hepatocytes ( tg(fabp10:nAtf6-cherry; cmlc2:GFP)-C allele). Samples were collected at 78 and 120 hpf to detect gene expression changes at early and late time points after nAtf6 is overexpressed.

ORGANISM(S): Danio rerio

PROVIDER: GSE130800 | GEO | 2019/05/08

REPOSITORIES: GEO

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