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Nano gold simulated autophagy prevents cell death

ABSTRACT: We showed a kind of rectangular shaped gold-based nanoparticles (gold nanocages, GNC) could enhance the survival of cells from hydroxyurea induced cell apoptosis and significantly reduced the reactive oxygen species (ROS) levels.The nanoparticles could initiate single layer isolation membrane elongation after been phagocytosed, followed by autophagosome and autolysosome formation, then specifically integrated into the autophagosome inner membrane and bind to p62. Through recycling ribosome proteins and activate Nrf2 mediated activation of GATA3 signaling, rescue the cell death and enhanced cell and life survival.

ORGANISM(S): Mus musculus

PROVIDER: GSE131033 | GEO | 2020/05/09

REPOSITORIES: GEO

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Nano gold simulated autophagy prevents cell death

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