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Effect of SAICAR accumulation on global transcription

ABSTRACT: We investigated the effects of SAICAR accumulation on transcriptional regulation of purine biosynthesis and other metabolic pathways. These data were compared to those obtained in the ade16ade17 vs WT comparison to determine the effects associated to accumulation of SAICAR alone. In this work, global transcription analyses were combined to measurements of intracellular nucleotides pools by HPLC. Keywords: Comparative genomic transcription analysis on total RNA from cells accumulating or not SAICAR.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE13184 | GEO | 2009/05/15

SECONDARY ACCESSION(S): PRJNA114101

REPOSITORIES: GEO

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Effect of AICAR and SAICAR accumulation on global transcription (first part)

Project description:We investigated the effects of AICAR and SAICAR accumulation on transcriptional regulation of purine biosynthesis and other metabolic pathways. In this work, global transcription analyses were combined to measurements of intracellular nucleotides pools by HPLC. Keywords: Comparative genomic transcription analysis on total RNA from cells accumulating or not AICAR and SAICAR nucleotide derivatives.

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