Transcriptomics

Dataset Information

0

Low-dose quercetin positively regulates mouse healthspan


ABSTRACT: we reported for the first time a geroprotective effect of low-dose quercetin alone that improved the healthspan of aged C57BL/6J male mice. Que-treated mice showed less hair loss, greater athletic endurance, enhanced diastolic function, and less muscle fibrosis, as well as alleviated cellular senescence in multiple tissues. Interestingly, these changes appear to be rarely associated with transcriptional alterations of protein-coding genes but are linked to heterochromatin stabilization and RTE silencing. Que treatment prevented L1 from hyperactivation, thereby inhibiting SASP.

ORGANISM(S): Mus musculus

PROVIDER: GSE132129 | GEO | 2019/06/04

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA545993 | ENA
2018-06-23 | GSE116166 | GEO
| PRJNA477529 | ENA
2022-09-27 | GSE178816 | GEO
2010-08-11 | GSE23523 | GEO
2009-12-10 | GSE13899 | GEO
2012-05-30 | GSE38136 | GEO
2008-01-01 | GSE7479 | GEO
2009-12-19 | E-GEOD-13899 | biostudies-arrayexpress
2023-12-01 | GSE219241 | GEO