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LSD1 regulates splenic B cell chromatin accessibility

ABSTRACT: To understand the role of LSD1 in splenic B cell development, spleens from mice with B cell conditional deletion of LSD1 were harvested, B220+CD93–GL7–CD23–CD21hiCD1d+ marginal zone B cells and B220+CD93–GL7–CD23+CD21midCD1d– follicular B cells were FACS-sorted, and ATAC-seq was performed to identify LSD1-target regulated chromatin.

ORGANISM(S): Mus musculus

PROVIDER: GSE132196 | GEO | 2019/08/06

REPOSITORIES: GEO

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LSD1 regulates the marginal zone B cell transcriptome

Project description:To understand the role of LSD1 in splenic B cell development, spleens from mice with B cell conditional deletion of LSD1 were harvested, B220+CD93–GL7–CD23–CD21hiCD1d+ marginal zone B cells and B220+CD93–GL7–CD23+CD21midCD1d– follicular B cells were FACS-sorted, and RNA-seq was performed to identify LSD1-target regulated genes.

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LSD1 regulates splenic B cell chromatin accessibility

Project description:LSD1 regulates splenic B cell chromatin accessibility

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