Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of Lithum on adult white matter

ABSTRACT: Analysis of adult murine optic nerves cultured for 3 days in vitro (DIV) ex-vivo in organotypic media containing saline or Lithium Chloride. Results provide insight on the mechanism of action of Lithium on glial cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE132397 | GEO | 2019/09/18

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Expression data for effect of LY294002 on White Matter

Project description:Characterisation of the effect of the PI3K/AKT modulator LY294002 in the murine optic nerve. Microarray analysis was performed using the Affymetrix Genechip Mouse 430 2.0 on murine optic nerves to identify bipartite effect of LY294002 on glia

2022-01-10 | GSE179189 | GEO

IL4 improves white matter repair after stroke

Project description:The repair of white matter damage is of paramount importance for functional recovery after brain injuries.We report that interleukin-4 (IL-4) promotes oligodendrocyte regeneration and remyelination. IL-4 receptor expression was detected in a variety of glial cells after ischemic brain injury, including oligodendrocyte lineage cells. IL-4 deficiency in knockout mice resulted in greater deterioration of white matter over 14 days after stroke. Consistent with these findings, intranasal delivery of IL-4 nanoparticles after stroke improved white matter integrity and attenuated long-term sensorimotor and cognitive deficits in wild-type mice, as revealed by histological immunostaining, electron microscopy, diffusion tensor imaging, and electrophysiology. The selective effect of IL-4 on remyelination was verified in an ex vivo organotypic model of demyelination. By leveraging primary oligodendrocyte progenitor cells (OPCs), microglia-depleted mice, and conditional OPC-specific PPARγ knockout mice, we discovered a direct salutary effect of IL-4 on oligodendrocyte differentiation that was mediated by the PPARγ axis. Our findings reveal a new regenerative role of IL-4 in the CNS, which lies beyond its known immunoregulatory functions on microglia/macrophages or peripheral lymphocytes. Therefore, intranasal IL-4 delivery may represent a novel therapeutic strategy to improve white matter integrity in stroke and other brain injuries.

2019-08-31 | GSE131774 | GEO

Transcriptomic analyses of astrocyte heterogeneity within white matter tracts

Project description:Astrocytes are broadly categorized as protoplasmic or fibrous, with the former localized to synaptically dense gray matter regions and the latter associated with axons in the white matter. Much of what we know about astrocyte form and function is derived from the study of protoplasmic astrocytes, whereas fibrous astrocytes remain relatively unexplored. We investigated the transcriptome of uninjured fibrous astrocytes in the mouse from three regions: unmyelinated optic nerve head (ONH), myelinated optic nerve proper (ONP), and corpus callosum (CC).

2022-11-29 | GSE211515 | GEO

Differential gene expression of Wnt agonist (BIO and lithium chloride) treated human dental pulp stem cells

Project description:Small molecules, BIO and Lithium chloride are widely used to activate Wnt signaling. It has been shown that these molecules induced beta-catenin accumulation and translocation, leading to the activation of Wnt signaling. These molecules also control various cell responses. Here, the differential gene expression of human dental pulp stem cells treated with BIO and Lithium chloride was examined using a high throughput RNA sequencing technique. Results demonstrated that BIO and Lithium chloride regulated the mRNA expression of various genes in human dental pulp stem cells.

2022-08-17 | GSE183633 | GEO

EAE Optic Nerves Injected with LPC 18:1 + Isobaric C13-His

Project description:EAE mice were injected with LPC 18:1 and Isobaric C13-His at the optic nerve when they exhibited a clinical score of 2. Visual function was assessed via pattern electroretinogram and optic nerves were harvested 12 days post optic nerve injection. Optic nerves were processed for mass spectrometry to identify the integration of C13-His in newly synthesized proteins.

2022-02-17 | PXD025176 | Pride

Expression data from P4 and P10 mouse optic nerves

Project description:Optic nerves are an accessible part of the CNS, providing a source of glia without the presence of neuronal cell bodies. Therefore, an analysis was carried out of gene expression in optic nerves at P4, before myelination begins and at P10, when myelination is very actively proceeding. The goal was to obtain a profile of the changing gene expression that accompanies this transition from unmyelinated CNS nerve to myelinated nerve. Two microarray experiments were combined here. In the first, RNA was prepared from the optic nerves of 75 P4 C57BL/6J mice and 70 P10 C57BL/6J mice. In the second experiment, RNA was prepared from the optic nerves of 55 P4 C57BL/6J mice and two groups of 50 P10 C57Bl/6J mice. In total, there are 2 P4 RNA samples and 3 P10 RNA samples being hybridized to Affymetrix GeneChip 430A for Mouse Expression.

2011-05-16 | E-GEOD-24513 | biostudies-arrayexpress

Retinal whole genome microarray analysis after irradiated injury of intraorbital nerve in the monkey

Project description:To obtain and analyze early retinal changes at molecular level at 24h after ipsilateral intraorbital nerve radiation injury by gamma knife surgery Unilateral intraorbital optic nerves of three Rhesus Macaques were treated by gamma knife surgery (GKS) with irradiated doses of 15Gy, while the contralateral optic nerves and retinas served as the control. Gene expression profiles of control and affected retinas were analyzed with Affymetrix Rhesus Macaque Genome arrays at 24h after treatment

2011-09-29 | E-GEOD-29901 | biostudies-arrayexpress

Mitochondrial transfer of the mutant human ND6T14484C gene causes visual loss and optic neuropathy

Project description:In this study we investigated the effects of mutant human ND6 on mouse optic nerves

2020-12-29 | GSE147920 | GEO

Transcriptomic changes of optic nerves under crush during hibernation stage

Project description:we compared the gene expression changes of crushed optic nerves from hibernating and awake squirrels.

2023-04-14 | GSE148651 | GEO

Nervous system injury establishes a microenvironment sufficient for brain tumor formation

Project description:To investigate the mechanism by which optic nerve crush induces microglia Ccl5 production, we performed bulk RNA sequencing on isolated optic nerves from crush- and sham-treatedNf1flox/flox;hGFAP-Cre miceat 3 months of age.

2024-02-07 | GSE233373 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data